Transfersomes: A Review for Transdermal Drug Delivery

Nayana D N, Shreya K, J Baseer UL Sumeer, Lingesh Kumar M S, Oyitabu Ifunanya Mercy, V. Kusum Devi, Vijaya G Joshi, Prachi Kabra, Nidhi Malviya, Rama Bukka, Rama Nargund, Shravan L. Nargund, Shachindra L. Nargund

Transfersomes, phosphatidylcholine, surfactants, Transdermal, gels

Transfersomes are advanced carriers for targeted transdermal drug delivery, composed of phosphatidylcholine and an edge activator. They penetrate the stratum corneum through intracellular and transcellular routes using an osmotic gradient. Their benefits include broad solubility, improved skin penetration, biocompatibility, and biodegradability, though they may face oxidative degradation and higher costs. Formulated through rotary evaporation and sonication, they include phospholipids, surfactants, and drugs. Key evaluation parameters include vesicle size, zeta potential, entrapment efficiency, drug content, and in vitro release. Transfersomes are ideal for controlled release, large molecule delivery, targeted subcutaneous distribution, and transdermal immunization, enhancing drug delivery effectively.

https://doi.org/10.31871/WJRR.20.5.25