Reflux of Duodenal Content Develop Esophageal Squamous Cell Carcinoma

Naoki Hashimoto

The incidence of esophageal cancer patients who have undergone distal gastrectomy is increasing recently. Distal gastrectomy is a good model for studying the clinical effects of duodenal content reflux.Individuals with a history of gastrectomy often suffer from sever alkaline reflux esophagitis. A history of gastrectomy is associated with an increased rate of lower third esophageal squamous cell carcinoma.Therefore,I made a rat model, a total gastrectomy followed by esophagoduodenostomy(n=27)was performed to induce chronic duodenal content reflux esophagitis. Esophageal squamous cell carcinoma (SCC) (40%)developed in places distant from the anastomosis compared to Esophageal adenocarcinoma (ADC) (30%). This means that histological features may depend on the volume of reflux contents; small amounts of reflux causes SCC and a large volume of reflux causes ADC.I concluded reflux of duodenal contents developed not only ADC but also SCC　from clinical and experimental data.

https://doi.org/10.31871/WJRR.4.2.14