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Volume 2 Issue 2

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Title : Intervertebral Disc Damage & Repair - its Pros And Cons

Authors : Mir Mahmoud Mortazavi R ,Annie John

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Abstract :

Incidence of Low Back Pain (LBP) is attributed to the degeneration of the intervertebral disc (IVD) occurring during the second or third decade of life. This has emerged as the most expensive global healthcare problem with costs in billion. The IVD comprises of an inner nucleus pulposus (NP) and an outer Annulus Fibrosis (AF). They act as cushions between the vertebrae of the vertebral column. Current treatment modalities involve conservative management (medication and physical therapy) or surgical intervention (spine fusion, total disc replacement (TDR), or NP replacement. Since the last decade, there has been a surge of interest in applying tissue-engineering principles (scaffold and cells) to treat spinal problems associated with IVD.


Title : Analysis of Complement Receptor Type 1 (CR1) Polymorphisms and Its Association With Malaria in Rural Population of Maharashtra

Authors : Kanchan Mahadik, Roshan Shaikh, Namrata Mahajan, Aarti Pandit, Shivam Shinde, Kanjaksha Ghosh, Ajit C. Gorakshakar

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Abstract :

The interaction between human host and the Plasmodium parasite is complex. The factors affecting the causality of infection and its severity are yet not completely understood. Single Nucleotide Polymorphisms (SNP) associated with CR1 may be associated with patho-physiology of malaria and its susceptibility to the disease. Methods: The objective of the present study was to calculate the incidence of various antigens of Knops blood group system and CR1 Exon22 polymorphisms in rural population from Chiplun Taluka of Ratnagiri district. The study included 112 malaria positive cases and 909 healthy controls, which were screened for CR1 Exon22 polymorphism. Knops (Kna/b), McCoy (McCa/b), Swain-Langley (Sl1/2) polymorphisms were screened in 93 cases and 321 healthy controls. The frequencies were determined using a PCR-RFLP technique. Results: Only wild types of the allele form were observed in Knops blood group system in malaria cases and healthy control. CR1 exon22 polymorphism was seen in the study population with all the 3 allele type distributed in the cases and control samples. No significant allelic or genotypic differences were found between the controls and the disease groups. Conclusion: The results of the present study demonstrate that common CR1 Exon22 and Knops blood group system are not associated with malaria in the endemic area.


Title : Managerial Capability and The Innovative Prowess of Entrepreneurial Firms in Nigeria

Authors : Oyedokun Akintunde Jonathan, Adegbile Aderibigbe Seun , Ogunkunle Oluwatobi James

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Abstract :

The relationship between managerial capability and the innovative prowess of entrepreneurs in the Nigeria plastic industry was examined to determine the extent to which management tactics stimulate the creativity of innovation in the industry. Two dimensional construct with six variables were advance for the study to capture the relationship between the identified capability and the innovative prowess of entrepreneurs. Structural equation model was used to analyze the data collected this was based on equation ability to validate propounded theory and show the multiple relationship among construct following their reliability and validation. The confirmatory factor analysis model displayed good fit following their assessment using three indices – absolute, incremental, parsimony. The result confirmed the test that managerial tactics displayed by management actually encouraged the stimulation of innovation that drive the creativity in the plastic industry.  Individual were not afraid to develop ideas and demonstrate such ideas since management promote and reward successful ideas that is sustainable. Managers were therefore recommended to identify and promote capabilities that can stimulate entrepreneurial innovation and healthy competition among employees in the industry.